Attraction to sexual pheromones and associated odorants in female mice involves activation of the reward system and basolateral amygdala

@article{MonchoBogani2005AttractionTS,
  title={Attraction to sexual pheromones and associated odorants in female mice involves activation of the reward system and basolateral amygdala},
  author={Jos{\'e} Moncho-Bogani and Fernando Mart{\'i}nez-Garc{\'i}a and Amparo Novejarque and Enrique Lanuza},
  journal={European Journal of Neuroscience},
  year={2005},
  volume={21}
}
Adult female mice are innately attracted to non‐volatile pheromones contained in male‐soiled bedding. In contrast, male‐derived volatiles become attractive if associated with non‐volatile attractive pheromones, which act as unconditioned stimulus in a case of Pavlovian associative learning. In this work, we study the chemoinvestigatory behaviour of female mice towards volatile and non‐volatile chemicals contained in male‐soiled bedding, in combination with the analysis of c‐fos expression… 
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It is found that VOC and MUP sex pheromones were differentiated in rats at around 8 weeks of age and that females separated from males at weaning showed no preference for male urine odor after sexual maturity, and it is suggested that olfactory preference is generated through repeated experience of either VOCs or a blend of V OCs and M UPs.
Have Sexual Pheromones Their Own Reward System in the Brain of Female Mice
TLDR
Previous results of the group indicating that female mice reared in the absence of male-derived chemosignals are ‘attracted’ by some components ofmale-soiled bedding, presumably detected by the vomeronasal organ are discussed.
Intraspecific communication through chemical signals in female mice: reinforcing properties of involatile male sexual pheromones.
TLDR
The present work constitutes the first demonstration of the unconditioned reinforcing properties of involatile, male-derived chemical signals, likely detected by the vomeronasal organ, steroid-dependent chemical signals in mammals.
DREADD-Induced Silencing of the Medial Olfactory Tubercle Disrupts the Preference of Female Mice for Opposite-Sex Chemosignals
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The medial olfactory tubercle appears to be a critical segment in the pheromone–reward pathway of female mice, implicated in the reinforcing effects of natural stimuli and drugs of abuse.
Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
TLDR
This involatile protein is a mammalian male sex pheromone that stimulates a flexible response to individual-specific odours through associative learning and memory, allowing female sexual attraction to be inherent but selective towards particular males.
Selective dopaminergic lesions of the ventral tegmental area impair preference for sucrose but not for male sexual pheromones in female mice
TLDR
The results indicate that partial lesions of the VTA reduce the preference for sucrose but do not alter the innate attraction that females display for male sexual pheromones, which can be interpreted as demonstrating the existence of separate neural mechanisms and circuits for signalling the reward of different natural reinforcers.
Neural and Hormonal Basis of Opposite-Sex Preference by Chemosensory Signals
TLDR
This review clarified the contradictions and deficiencies in current knowledge on the neuroendocrine regulation of sexual preference and sought to present problems requiring further study.
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Attractive properties of sexual pheromones in mice Innate or learned?
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TLDR
The results suggest that the VNO is not required for sex discrimination but instead detects the nonvolatile components of opposite-sex urine that may be used to help prolong contact with individuals that produce these chemosignals.
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TLDR
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TLDR
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TLDR
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