Attracting AID to targets of somatic hypermutation

  title={Attracting AID to targets of somatic hypermutation},
  author={Atsushi Tanaka and Hong Ming Shen and Sarayu Ratnam and Prashant Kodgire and Ursula Storb},
  booktitle={The Journal of experimental medicine},
The process of somatic hypermutation (SHM) of immunoglobulin (Ig) genes requires activation-induced cytidine deaminase (AID). Although mistargeting of AID is detrimental to genome integrity, the mechanism and the cis-elements responsible for targeting of AID are largely unknown. We show that three CAGGTG cis-elements in the context of Ig enhancers are sufficient to target SHM to a nearby transcribed gene. The CAGGTG motif binds E47 in nuclear extracts of the mutating cells. Replacing CAGGTG… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 25 extracted citations


Publications referenced by this paper.
Showing 1-10 of 49 references

A role for histone acetylation in the developmental regulation of VDJ recombination

  • N. Michael, H. M. Shen, S. Longerich, N. Kim, A. Longacre, U. Storb
  • Science .
  • 2003
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…