Attracting AID to targets of somatic hypermutation

@inproceedings{Tanaka2010AttractingAT,
  title={Attracting AID to targets of somatic hypermutation},
  author={Atsushi Tanaka and Hong Ming Shen and Sarayu Ratnam and Prashant Kodgire and Ursula Storb},
  booktitle={The Journal of experimental medicine},
  year={2010}
}
The process of somatic hypermutation (SHM) of immunoglobulin (Ig) genes requires activation-induced cytidine deaminase (AID). Although mistargeting of AID is detrimental to genome integrity, the mechanism and the cis-elements responsible for targeting of AID are largely unknown. We show that three CAGGTG cis-elements in the context of Ig enhancers are sufficient to target SHM to a nearby transcribed gene. The CAGGTG motif binds E47 in nuclear extracts of the mutating cells. Replacing CAGGTG… CONTINUE READING

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