Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function.

@article{Wrenger2006AttractinAD,
  title={Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function.},
  author={Sabine Wrenger and J{\"u}rgen Faust and Daniel Friedrich and Torsten Andreas Hoffmann and Roland Hartig and Uwe Lendeckel and Thilo K{\"a}hne and Anja Thielitz and Klaus Neubert and Dirk Reinhold},
  journal={Journal of leukocyte biology},
  year={2006},
  volume={80 3},
  pages={621-9}
}
The ectoenzyme dipeptidyl peptidase IV (DP IV; CD26) was shown to play a crucial role in T cell activation. Several compounds inhibiting DP IV-like activity are currently under investigation for the treatment of Type 2 diabetes, rheumatoid arthritis, colitis ulcerosa, psoriasis, multiple sclerosis, and other diseases. In the present study, we show that human peripheral blood monocytes express a DP IV-like enzyme activity, which could be inhibited completely by the synthetic DP IV inhibitor Lys… CONTINUE READING