Attomolar Zika virus oligonucleotide detection based on loop-mediated isothermal amplification and AC susceptometry.

@article{Tian2016AttomolarZV,
  title={Attomolar Zika virus oligonucleotide detection based on loop-mediated isothermal amplification and AC susceptometry.},
  author={Bo Tian and Zhen Qiu and Jing Ma and Teresa Zard{\'a}n G{\'o}mez de la Torre and Christer Johansson and Peter Svedlindh and Mattias Str{\"o}mberg},
  journal={Biosensors & bioelectronics},
  year={2016},
  volume={86},
  pages={420-425}
}
Because of the serological cross-reactivity among the flaviviruses, molecular detection methods, such as reverse-transcription polymerase chain reaction (RT-PCR), play an important role in the recent Zika outbreak. However, due to the limited sensitivity, the detection window of RT-PCR for Zika viremia is only about one week after symptom onset. By combining loop-mediated isothermal amplification (LAMP) and AC susceptometry, we demonstrate a rapid and homogeneous detection system for the Zika… CONTINUE READING

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