Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase

  title={Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase},
  author={Aditi Chawla and Sutapa Chakrabarti and Gourisankar Ghosh and Maho Niwa},
  booktitle={The Journal of cell biology},
The unfolded protein response (UPR) activates Ire1, an endoplasmic reticulum (ER) resident transmembrane kinase and ribonuclease (RNase), in response to ER stress. We used an in vivo assay, in which disappearance of the UPR-induced spliced HAC1 messenger ribonucleic acid (mRNA) correlates with the recovery of the ER protein-folding capacity, to investigate the attenuation of the UPR in yeast. We find that, once activated, spliced HAC1 mRNA is sustained in cells expressing Ire1 carrying… CONTINUE READING

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