Attenuation of virus-induced myocardial injury by inhibition of the angiotensin II type 1 receptor signal and decreased nuclear factor-kappa B activation in knockout mice.

@article{Yamamoto2003AttenuationOV,
  title={Attenuation of virus-induced myocardial injury by inhibition of the angiotensin II type 1 receptor signal and decreased nuclear factor-kappa B activation in knockout mice.},
  author={Kanjo Yamamoto and Tetsuo Shioi and Koji Uchiyama and Tadashi Miyamoto and Shigetake Sasayama and Akira Matsumori},
  journal={Journal of the American College of Cardiology},
  year={2003},
  volume={42 11},
  pages={
          2000-6
        }
}
OBJECTIVES This study examined the role of angiotensin II (Ang-II) in a murine model of viral myocarditis. BACKGROUND Ang-II plays an important role in the pathophysiology of various cardiovascular disorders. However, the role of Ang-II in inflammatory heart diseases is not known. METHODS Four-week-old wild-type (WT) and Ang-II type 1 receptor (AT(1)R) knockout (KO) mice were inoculated with the encephalomyocarditis virus (EMCV). Survival, histopathology, expression of proinflammatory… CONTINUE READING
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Substance P is required for the pathogenesis of EMCV infection in mice.

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