Attenuation of the pancreatic beta cell response to a meal following hypoglycaemia in man

@article{Frier1980AttenuationOT,
  title={Attenuation of the pancreatic beta cell response to a meal following hypoglycaemia in man},
  author={Brian M Frier and Roger J M Corrall and Joanne Ashby and Joyce D. Baird},
  journal={Diabetologia},
  year={1980},
  volume={18},
  pages={297-300}
}
The plasma concentration of C-peptide, insulin (IRI) and glucose was measured in 9 healthy subjects during insulin-induced hypoglycaemia followed by a meal. Identical observations were made in the same subjects after an equivalent period of fasting without hypoglycaemia (control study). Endogenous secretion of insulin was suppressed following administration of exogenous insulin and this persisted long after the blood glucose concentration had returned to normal. After the meal the mean blood… CONTINUE READING
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