Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation.

  title={Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation.},
  author={Hanna Appelqvist and Cathrine Nilsson and Brett Garner and Andrew J Brown and Katarina M K{\aa}gedal and Karin M Ollinger},
  journal={The American journal of pathology},
  volume={178 2},
In the past decade, lysosomal membrane permeabilization (LMP) has emerged as a significant component of cell death signaling. The mechanisms by which lysosomal stability is regulated are not yet fully understood, but changes in the lysosomal membrane lipid composition have been suggested to be involved. Our aim was to investigate the importance of cholesterol in the regulation of lysosomal membrane permeability and its potential impact on apoptosis. Treatment of normal human fibroblasts with… CONTINUE READING


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