Attenuation of the effects of chronic ethanol administration in the brain lipid content of the developing rat by an oil enriched in gamma linolenic acid.

  title={Attenuation of the effects of chronic ethanol administration in the brain lipid content of the developing rat by an oil enriched in gamma linolenic acid.},
  author={Orla Duffy and Jean François Menez and Brian E. Leonard},
  journal={Drug and alcohol dependence},
  volume={31 1},
Effects of postnatal ethanol exposure on brain growth and lipid composition in n−3 fatty acid-deficient and-adequate rats
While ethanol had some effects on lipid composition, there was no difference between the dietary groups in their vulnerability to the effects of early short-term ethanol exposure on brain growth.
The effects of polyunsaturated fatty acids in alcohol dependence treatment - a double-blind, placebo-controlled pilot study
The oral supplementation of 2 g PUFAS for 3 months did not significantly differ from placebo in reducing the amount of alcohol ingestion, or OCDS and SADD scores in a group of alcohol dependent patient.
Le rôle des acides gras polyinsaturés dans la prévention des effets de l'exposition prénatale à l'alcool sur le développement des nouveau-nés inuits : une étude épidémiologique
In this population in which infrequent heavy episodic drinking is common, even occasional binge exposure was associated with reduced prenatal growth and poorer visual acuity at 6 months of age, and a simple dichotomous measure of binge drinking during pregnancy provided the best predictor of fetal growth and 6-month acuity.
OMEGA-3 Interventions in Alcohol Dependence and Related Outcomes: A Systematic Review and Propositions
Despite the reduced number of studies, omega-3 interventions seem to be promising for controlling issues related to alcohol dependence.
Chemical Information Review Document for Evening Primrose Oil ( Oenothera biennis L . ) [ CAS No . 90028-66-3 ]
  • Biology, Medicine
  • 2009
Results from studies of EPO's carcinogenic effects were conflicting; EPO increased the mean tumor mass in C57 mice transplanted with BL6 melanoma cells but had no effect on either tumor growth in mice that had murine sarcoma allografts or tumor incidence in CD-1 mice.


The effects of chronic administration of ethanol on synaptosomal fatty acid composition: modulation by oil enriched with gamma-linolenic acid.
The results suggest that the decrease of arachidonate, especially in PI, caused by chronic administration of ethanol may be overcome by systemic administration of gamma-linolenic acid.
Changes in whole brain membranes of rats following pre- and post-natal exposure to ethanol.
It seems likely that, in the immature animal, the brain is still undergoing rapid development and therefore may be affected differentially by ethanol, which is contrary to those found in adult rats following chronic ethanol administration.
gamma-Linolenic acid fails to prevent the effects of prenatal ethanol exposure on brain and behavioral development in B6D2F2 mice.
The data did not support the hypothesis that GLA would prevent the deleterious effects of prenatal ethanol exposure, and the results indicated that reproductive outcome, as measured by animals which produced live pups, was worse in the GLA- and AA-treated groups.
A possible essential role for dietary linolenic acid in the development of the young rat.
The association of superior learning capacity with dietary soybean oil-induced incorporation of omega3 fatty acids into the brain glycerophosphatides is offered as support for an essential role for dietary linolenic acid for the young rat.
Effects of dietary phospholipids and odd-chain fatty acids on the behavioural maturation of mice.