Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice.

  title={Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice.},
  author={Mufida B. El-Ghundi and Brian F O'dowd and Mary S Erclik and Susan R. George},
  journal={The European journal of neuroscience},
  volume={17 4},
Dopaminergic systems are thought to mediate the rewarding and reinforcing effects of palatable food. However, the relative contribution of different dopamine receptor subtypes is not clear. We used dopamine D1 receptor deficient mice (D1 -/-) and their wild-type and heterozygous littermates to study the role of the D1 receptor in palatable food reinforced behaviour using operant responding and free access paradigms. Non-deprived mice were trained to press a lever for sucrose pellets under three… CONTINUE READING
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