Attenuation of sleep propensity, core hypothermia, and peripheral heat loss after temazepam tolerance.

  title={Attenuation of sleep propensity, core hypothermia, and peripheral heat loss after temazepam tolerance.},
  author={Saul S. Gilbert and Helen J. Burgess and David J. Kennaway and Drew Dawson},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={279 6},
  • S. Gilbert, H. Burgess, D. Dawson
  • Published 1 December 2000
  • Psychology, Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
If changes in thermoregulation mediate sleepiness induced by sedative/hypnotics, then a reduction in the soporific efficacy (tolerance) of these agents may be accompanied by a concomitant reduction in their thermoregulatory effects. We compared the thermoregulatory and soporific effects of acute temazepam (30 mg at 1400) in 11 young male subjects before and immediately after 7 consecutive days of temazepam (30 mg). Subjects lay supine (0800-2030), while foot (T(ft)) and rectal (T(c… 

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