Attenuation of sleep propensity, core hypothermia, and peripheral heat loss after temazepam tolerance.

@article{Gilbert2000AttenuationOS,
  title={Attenuation of sleep propensity, core hypothermia, and peripheral heat loss after temazepam tolerance.},
  author={Saul S. Gilbert and Helen J. Burgess and David J. Kennaway and Drew Dawson},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2000},
  volume={279 6},
  pages={
          R1980-7
        }
}
  • S. Gilbert, H. Burgess, +1 author D. Dawson
  • Published 2000
  • Psychology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
If changes in thermoregulation mediate sleepiness induced by sedative/hypnotics, then a reduction in the soporific efficacy (tolerance) of these agents may be accompanied by a concomitant reduction in their thermoregulatory effects. We compared the thermoregulatory and soporific effects of acute temazepam (30 mg at 1400) in 11 young male subjects before and immediately after 7 consecutive days of temazepam (30 mg). Subjects lay supine (0800-2030), while foot (T(ft)) and rectal (T(c… Expand
Heat Loss, Sleepiness, and Impaired Performance after Diazepam Administration in Humans
TLDR
Distal−p-BT gradient (DPG; difference between d-BT and p-BT), which is an indicator of blood flow in distal skin regions, showed a strong positive correlation with the plasma DZp concentration, indicating that DZP in clinical doses promotes heat loss in a dose-dependent manner. Expand
Melatonin and zopiclone: the relationship between sleep propensity and body temperature.
TLDR
The results suggest that body temperature changes may be a general feature of sedative-hypnotics and the potential role of this effect in the promotion of sleep appears to vary between agents. Expand
Attenuated thermoregulatory response to mild thermal challenge in subjects with sleep-onset insomnia.
TLDR
SOI were observed to have significantly attenuated thermoregulatory responses to a mild positive thermal challenge, providing evidence that impaired heat loss capacity from the periphery is associated with sleep onset insomnia. Expand
Thermoregulation in wakefulness and sleep in humans.
TLDR
It is shown that sleep cannot be scheduled no matter when—it needs to be prepared, as suggested by the discrete thermoregulatory changes observed prior to sleep, and that alterations in one rhythm do not systematically modify the other. Expand
Acute Finger Temperature Changes Preceding Sleep onsets using Labview
Resurgence in the field of sleep initiation and thermoregulation has seen a number of investigators reporting relatively gradual increases in distal skin temperatures of the hands and feet prior toExpand
Acute finger temperature changes preceding sleep onsets over a 45‐h period
TLDR
Investigating whether a change of distal skin temperature triggered specifically by the attempt to fall asleep and whether this relationship holds for various phases of the circadian rhythm whenever sleep is attempted extends upon prior knowledge. Expand
Distal Cooling and Sustained Attention
Introduction: Vigilance is directly related to core and skin temperatures (TC and Tsk). Biological day reflects a high TC and alertness; night reflects vice versa. At rest, TC is regulated largely byExpand
Effects of humid heat exposure in later sleep segments on sleep stages and body temperature in humans
TLDR
It is suggested that humid heat Exposure in the later sleep segment reduces thermal load as compared to full-night humid heat exposure and the use of air conditioning in the initial sleep hours can protect sleep and thermoregulation. Expand
Enhanced Heat Loss and Age-Related Hypersensitivity to Diazepam
TLDR
Findings suggest that hypersensitivity to benzodiazepine in older persons may be due, at least in part, to age-related changes in thermoregulation, especially in the heat loss process. Expand
Thermoregulation as a sleep signalling system.
TLDR
A model where thermoregulatory changes provide an additional signal to the brain regions that regulate sleep and wakefulness is proposed and attempts to explain how temperature changes before and after sleep onset act in a positive feedback loop to maintain a consolidated sleep bout. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 25 REFERENCES
Daytime melatonin and temazepam in young adult humans: equivalent effects on sleep latency and body temperatures
TLDR
A possible role of thermoregulation in sleep initiation is suggested by the similar temporal relationship between Tc and SOL for two different classes of soporific agents. Expand
A relationship between heat loss and sleepiness: effects of postural change and melatonin administration.
TLDR
Findings suggest that under comfortable ambient temperature conditions, heat loss via the distal skin regions (e.g., feet) is a key mechanism for induction of sleepiness as core body temperature declines. Expand
Hypothermic effect of melatonin and nocturnal core body temperature decline are reduced in aged women.
TLDR
The data show that, in women, an aging-associated reduction of temperature responses to melatonin is probably involved in inducing an attenuation of the nocturnal Tc decline and circadian Tc rhythm amplitude. Expand
Differences in sleep variables, blood adenosine, and body temperature between hypothyroid and euthyroid rats before and after REM sleep deprivation.
TLDR
The main findings were that Htx animals exhibited a significant reduction in blood thyroid hormones (T3, T4, and thyroid-stimulating hormone (TSH) and that they also had high levels of plasma adenosine, which may explain the increase in delta sleep in this group. Expand
Melatonin and S-20098 increase REM sleep and wake-up propensity without modifying NREM sleep homeostasis.
TLDR
A single early evening dose of melatonin or the agonist S-20098 increases REM sleep propensity and advances sleep termination while, at the same time, the EEG in NREM sleep remains unaffected. Expand
Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance.
TLDR
The data indicate that orally administered melatonin can be a highly potent hypnotic agent and suggest that the physiological increase in serum melatonin levels, which occurs around 2100 h daily, may constitute a signal initiating normal sleep onset. Expand
Changes in sleepiness and body temperature precede nocturnal sleep onset: Evidence from a polysomnographic study in young men
TLDR
From results, it is reasonable to infer that a sequence of thermoregulatory and sleep propensity changes occur before, but are associated with habitual sleep onset, as the changes are significantly attenuated if sleep is delayed. Expand
Early evening melatonin and S-20098 advance circadian phase and nocturnal regulation of core body temperature.
TLDR
The data suggest that, in addition to immediate thermoregulatory changes, a phase advance of the circadian system had occurred and that the phase advance could still be measured on the posttreatment day. Expand
Respiratory and psychological effects of oral temazepam in volunteers.
In a double-blind comparison with placebo the time-course of the effects of temazepam 40 mg and 20 mg on breathing, arterial pressure, oral temperature, cognitive function, psychomotor performanceExpand
Role of adenosine in sleep and temperature regulation in the preoptic area of rats
TLDR
A site for the central hypnotic action ofadenosine, and a functional role for adenosine A1 receptors in the hypothalamus are demonstrated. Expand
...
1
2
3
...