Attenuation of skeletal muscle atrophy in cancer cachexia by d-myo-inositol 1,2,6-triphosphate

@article{Russell2008AttenuationOS,
  title={Attenuation of skeletal muscle atrophy in cancer cachexia by d-myo-inositol 1,2,6-triphosphate},
  author={Steven Thomas Russell and Pontus M A Siren and Matti J Siren and Michael John Tisdale},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2008},
  volume={64},
  pages={517-527}
}
To determine the effectiveness of the polyanionic, metal binding agent d-myo-inositol-1,2,6-triphosphate (alpha trinositol, AT), and its hexanoyl ester (HAT), in tissue wasting in cancer cachexia. The anti-cachexic effect was evaluated in the MAC16 tumour model. Both AT and HAT attenuated the loss of body weight through an increase in the nonfat carcass mass due to an increase in protein synthesis and a decrease in protein degradation in skeletal muscle. The decrease in protein degradation was… CONTINUE READING

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Protein synthesis was increased due to attenuation of the elevated autophosphorylation of double - stranded RNA - dependent protein kinase , and of eukaryotic initiation factor 2α together with hyperphosphorylation of eIF4E - binding protein 1 and decreased phosphorylation of eukaryotic elongation factor 2 .
Protein synthesis was increased due to attenuation of the elevated autophosphorylation of double - stranded RNA - dependent protein kinase , and of eukaryotic initiation factor 2α together with hyperphosphorylation of eIF4E - binding protein 1 and decreased phosphorylation of eukaryotic elongation factor 2 .
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