Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase knockout mice.

@article{Ling1999AttenuationOR,
  title={Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase knockout mice.},
  author={H Ling and C Edelstein and Patricia E Gengaro and X Meng and S Lucia and M Knotek and Adisorn Wangsiripaisan and Y Shi and R Schrier},
  journal={The American journal of physiology},
  year={1999},
  volume={277 3 Pt 2},
  pages={F383-90}
}
  • H Ling, C Edelstein, +6 authors R Schrier
  • Published 1999 in The American journal of physiology
Renal ischemia-reperfusion (I/R) injury was investigated in inducible nitric oxide synthase (iNOS) knockout mice. After a 26-min bilateral renal pedicle clamp, serum creatinine concentrations (in mg/dl) in wild-type mice after a 24-h reperfusion were 0.25 +/- 0.03 in sham-operated controls and 2.3 +/- 0.38 in ischemic mice (P < 0. 01); after 48 h, concentrations (in mg/dl) were 0.25 +/- 0.03 in controls and 2.0 +/- 0.18 in ischemic mice (P < 0.01). iNOS knockout mice demonstrated an attenuation… CONTINUE READING
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