Attenuation of proteolysis and muscle wasting by curcumin c3 complex in MAC16 colon tumour-bearing mice.

@article{Siddiqui2009AttenuationOP,
  title={Attenuation of proteolysis and muscle wasting by curcumin c3 complex in MAC16 colon tumour-bearing mice.},
  author={Rafat Ali Siddiqui and Samira Hassan and Kevin A. Harvey and Tamkeen Rasool and Tapas Ranjan Das and Pradip Mukerji and Stephen Joseph Demichele},
  journal={The British journal of nutrition},
  year={2009},
  volume={102 7},
  pages={
          967-75
        }
}
Muscle wasting or cachexia is caused by accelerated muscle protein breakdown via the ubiquitin-proteasome complex. We investigated the effect of curcumin c3 complex (curcumin c3) on attenuation of muscle proteolysis using in vitro and in vivo models. Our in vitro data indicate that curcumin c3 as low as 0.50 microg/ml was very effective in significantly inhibiting (30 %; P < 0.05) tyrosine release from human skeletal muscle cells, which reached a maximum level of inhibition of 60 % (P < 0.05… CONTINUE READING

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