Attenuation of postischemic reperfusion injury is related to prevention of [Ca2+]m overload in rat hearts.

@article{Miyamae1996AttenuationOP,
  title={Attenuation of postischemic reperfusion injury is related to prevention of [Ca2+]m overload in rat hearts.},
  author={Masami Miyamae and S. Albert Camacho and Michael W Weiner and Vincent M Figueredo},
  journal={The American journal of physiology},
  year={1996},
  volume={271 5 Pt 2},
  pages={H2145-53}
}
Intracellular calcium overload has been implicated in postischemic reperfusion injury. In myocytes, mitochondrial free calcium concentration ([Ca2+]m), not cytosolic free calcium concentration ([Ca2+]c), overload is related to reoxygenation injury. We tested the hypothesis that [Ca2+]m, not [Ca2+]c, overload is an important mediator of reperfusion injury in whole hearts. [Ca2+]m and [Ca2+]c were assessed using indo 1 fluorescence in isolated rat hearts subjected to 45 min of ischemia and 20 min… CONTINUE READING

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