Attenuation of phagocytosis of xenogeneic cells by manipulating CD47.

  title={Attenuation of phagocytosis of xenogeneic cells by manipulating CD47.},
  author={Hui Wang and Jon P VerHalen and Maria Lucia L Madariaga and Shuanglin Xiang and Shumei Wang and Ping Lan and P. -A. Oldenborg and Megan Sykes and Yong-Guang Yang},
  volume={109 2},
Signal regulatory protein alpha (SIRPalpha) is a critical immune inhibitory receptor on macrophages, and its interaction with CD47, a ligand for SIRPalpha, prevents autologous phagocytosis. We hypothesized that interspecies incompatibility of CD47 may contribute to the rejection of xenogeneic cells by macrophages. Here, we show that pig CD47 does not interact with mouse SIPRalpha. Similar to CD47-/- mouse cells, porcine red blood cells (RBCs) failed to induce SIRPalpha tyrosine phosphorylation… CONTINUE READING
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CD47 is a ligand for rat macrophage membrane signal CD47-SIRP SIGNALING AND MACROPHAGE XENOREACTIVITY

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