Attenuation of oxidative and nitrosative stress in cortical area associates with antidepressant-like effects of tropisetron in male mice following social isolation stress

@article{HajMirzaian2016AttenuationOO,
  title={Attenuation of oxidative and nitrosative stress in cortical area associates with antidepressant-like effects of tropisetron in male mice following social isolation stress},
  author={A. Haj‐Mirzaian and S. Amiri and Hossein Amini-Khoei and M. Rahimi-Balaei and S. E. Mehr},
  journal={Brain Research Bulletin},
  year={2016},
  volume={124},
  pages={150-163}
}
Tropisetron, a 5-HT3 receptor antagonist widely used as an antiemetic, has been reported to have positive effects on mood disorders. Adolescence is a critical period during the development of brain, where exposure to chronic stress during this time is highly associated with the development of depression. In this study, we showed that 4 weeks of juvenile social isolation stress (SIS) provoked depressive-like behaviors in male mice, which was associated with disruption of mitochondrial function… Expand
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