Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway

@inproceedings{Wei2012AttenuationOO,
  title={Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway},
  author={Fangyuan Wei and Douglas C. Moore and Yanlin Li and Ge Zhang and Xiao-chun Wei and Joseph K. T. Lee and Lei Wei},
  booktitle={Arthritis research & therapy},
  year={2012}
}
INTRODUCTION This study was performed to evaluate the attenuation of osteoarthritic (OA) pathogenesis via disruption of the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) signaling with AMD3100 in a guinea pig OA model. METHODS OA chondrocytes and cartilage explants were incubated with SDF-1, siRNA CXCR4, or anti-CXCR4 antibody before treatment with SDF-1. Matrix metalloproteases (MMPs) mRNA and protein levels were measured with real-time polymerase chain… CONTINUE READING
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