Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice.

@article{Xu2010AttenuationOO,
  title={Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice.},
  author={Ling Xu and Jacqueline M Servais and Ilona Polur and D. S. Kim and Peter L. Lee and Kimberly R. Chung and Yefu Li},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 9},
  pages={2736-44}
}
OBJECTIVE To investigate whether the reduction of discoidin domain receptor 2 (DDR-2), a cell membrane tyrosine kinase receptor for native type II collagen, attenuates the progression of articular cartilage degeneration in mouse models of osteoarthritis (OA). METHODS Double-heterozygous (type XI collagen-deficient [Col11a1(+/-)] and Ddr2-deficient [Ddr2(+/-)]) mutant mice were generated. Knee joints of Ddr2(+/-) mice were subjected to microsurgical destabilization of the medial meniscus… CONTINUE READING

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