Attenuation of nicotine-induced rewarding effects in A2A knockout mice.

  title={Attenuation of nicotine-induced rewarding effects in A2A knockout mice.},
  author={A. Castane and Guadalupe Soria and Catherine A. Ledent and Rafael Maldonado and Olga Valverde},
  volume={51 3},
The non-selective A2A antagonist caffeine has been reported to modify nicotine-induced locomotor and reinforcing effects. In the present study, we have investigated the specific role of A2A adenosine receptors in the behavioural responses induced by nicotine by using genetically modified mice lacking A2A adenosine receptors. Acute nicotine administration induced a similar decrease of locomotor activity in A2A knockout mice and wild-type littermates. Acute antinociceptive responses elicited by… CONTINUE READING
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