Attenuation of myocardial reperfusion injury in pigs by Mirococept, a membrane-targeted complement inhibitor derived from human CR1.

@article{Banz2007AttenuationOM,
  title={Attenuation of myocardial reperfusion injury in pigs by Mirococept, a membrane-targeted complement inhibitor derived from human CR1.},
  author={Yara Banz and Otto Martin Hess and Simon Christopher Robson and Eva Csizmadia and Daniel Mettler and Pascal Meier and Andr{\'e} Haeberli and Sidney Shaw and Richard A. G. Smith and Robert N. Rieben},
  journal={Cardiovascular research},
  year={2007},
  volume={76 3},
  pages={482-93}
}
OBJECTIVES Membrane-targeted application of complement inhibitors may ameliorate ischemia/reperfusion (I/R) injury by directly targeting damaged cells. We investigated whether Mirococept, a membrane-targeted, myristoylated peptidyl construct derived from complement receptor 1 (CR1) could attenuate I/R injury following acute myocardial infarction in pigs. METHODS In a closed-chest pig model of acute myocardial infarction, Mirococept, the non-tailed derivative APT154, or vehicle was… CONTINUE READING

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