Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver.

@article{Hanawa2006AttenuationOM,
  title={Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver.},
  author={Takayasu Hanawa and Kenji Suzuki and Yusuke Kawauchi and Masaaki Takamura and Hiroyuki Yoneyama and Gi Dong Han and Hiroshi Kawachi and Fujio Shimizu and Hitoshi Asakura and Jun-Ichi Miyazaki and Hiroki Maruyama and Yutaka Aoyagi},
  journal={The journal of gene medicine},
  year={2006},
  volume={8 5},
  pages={623-35}
}
BACKGROUND Hepatocyte growth factor (HGF) has multiple biological effects on a wide variety of cells. It modulates intestinal epithelial proliferation and migration, and critically regulates intestinal wound healing. AIMS To investigate the therapeutic effect of HGF gene transfer, we introduced the HGF gene into the liver of mice with acute colitis. METHODS The rat HGF expression plasmid vector, pCAGGS-HGF, was injected via the tail vein into C57BL/6 mice, followed by dosing with dextran… CONTINUE READING

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