Attenuation of microRNA-16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertrophy

@inproceedings{Huang2015AttenuationOM,
  title={Attenuation of microRNA-16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertrophy},
  author={Shuai Huang and Xiao Zou and Jie-ning Zhu and Yong-heng Fu and Qiu-xiong Lin and Ye-You Liang and Chun-yu Deng and Su-juan Kuang and Meng-Zhen Zhang and Yu-lin Liao and Xi-long Zheng and Xi-Yong Yu and Z. R. Shan},
  booktitle={Journal of cellular and molecular medicine},
  year={2015}
}
Cyclins/retinoblastoma protein (pRb) pathway participates in cardiomyocyte hypertrophy. MicroRNAs (miRNAs), the endogenous small non-coding RNAs, were recognized to play significant roles in cardiac hypertrophy. But, it remains unknown whether cyclin/Rb pathway is modulated by miRNAs during cardiac hypertrophy. This study investigates the potential role of microRNA-16 (miR-16) in modulating cyclin/Rb pathway during cardiomyocyte hypertrophy. An animal model of hypertrophy was established in a… CONTINUE READING
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