Attenuation of luteinizing hormone surges in neuropeptide Y knockout mice.

  title={Attenuation of luteinizing hormone surges in neuropeptide Y knockout mice.},
  author={Min Xu and Jennifer W. Hill and John E Levine},
  volume={72 5},
To clarify the role of neuropeptide Y (NPY) in the regulation of the reproductive axis, these experiments evaluated the extent to which reproductive hormone secretions may be compromised in the absence of NPY expression. In NPY knockout (NPY-KO) and wild-type (WT) mice, hormone secretions were analyzed under conditions of basal release, following ovariectomy (OVX), in proestrus, after estrogen treatments which induce gonadotropin surges and after injection of gonadotropin-releasing hormone… CONTINUE READING


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