Attenuation of ischemic efflux of endogenous amino acids by the novel 5-HT1A/5-HT2 receptor ligand adatanserin

@article{Dawson2002AttenuationOI,
  title={Attenuation of ischemic efflux of endogenous amino acids by the novel 5-HT1A/5-HT2 receptor ligand adatanserin},
  author={Lee A. Dawson and J. Galandak and Sina Djali},
  journal={Neurochemistry International},
  year={2002},
  volume={40},
  pages={203-209}
}
Repeated Cocaine Administration Decreases 5-HT2A Receptor-Mediated Serotonergic Enhancement of Synaptic Activity in Rat Medial Prefrontal Cortex
TLDR
Cocaine-induced inhibition of 5-HT2A receptor-mediated enhancement of glutamatergic transmission in the mPFC may be caused, at least in part, by the impairment of coupling of 4-iodo-2,5-dimethoxyphenylisopropylamine and GTP-binding proteins during cocaine withdrawal.
Ketanserin reduces the postischemic EEG and behavioural changes following Endothelin-1-induced occlusion of the middle cerebral artery in conscious rats
TLDR
Results showed that treatment with ketanserin at the early stage of stroke may reduce the consequences of ischemia by improvement of functional and morphological recovery at later stages.
ENDOTHELIN-1-INDUCED CEREBRAL ISCHEMIA: EFFECTS OF KETANSERIN AND MK-801 ON LIMB PLACING IN RATS
TLDR
The present results suggest that pharmacotherapy by means of ketanserin lacking the severe side effects of the NMDA antagonists can be used to enhance functional recovery after stroke.
Modulation of ASIC1a function by sigma-1 receptors: Physiological and pathophysiological implications
TLDR
The hypothesis presented is that sigma receptor activation inhibits ASIC1a function and ASIC1A-induced [Ca]i elevations during acidosis and ischemia, which may be a mechanism by which sigma ligands provide neuroprotection following stroke.
Functional Pharmacology in Human Brain
TLDR
The use of neurosurgically removed fresh human brain tissue samples in which receptors, transporters, ion channels, and enzymes essentially retain their natural environment represents a unique experimental approach to enlarge the understanding of human brain processes and to help in the choice of appropriate animal models.
Facile Synthesis of N-{2-[4-(2-Pyrimidinyl)-1-Piperazinyl]ethyl} Adamantane-1-Carboxamide
A facile method for the synthesis of N-{2-[4-(2-pyrimidinyl)-1-piperazinyl]ethyl} adamantane-1-carboxamide(Adatanserin) was developed by using 2-chloropyrimidine and adamantanecarbonyl chloride as

References

SHOWING 1-10 OF 37 REFERENCES
Characterization of Endogenous Amino Acid Efflux from Hippocampal Slices during Chemically-Induced Ischemia
TLDR
It would appear that the increases in amino acid efflux induced by chemical ischemia originates from both the neuronal pool, via conventional exocytotic release, and glial sources via reversal of the GLT-1 transporter and anion channel regulated cell swelling.
Role of hippocampal serotonergic neurons in ischemic neuronal death
...
1
2
3
4
...