Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation.

@article{Lin2004AttenuationOI,
  title={Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation.},
  author={Angello Lin and Charanpal Sekhon and Bipanjeet Sekhon and Allyson Smith and Kenneth Chavin and John K. Orak and Inderjit Singh and Avtar Jit Singh},
  journal={Transplantation},
  year={2004},
  volume={78 5},
  pages={
          654-9
        }
}
BACKGROUND This study examined the potential therapeutic effects of a combination therapy consisting of 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR) and N-acetyl cysteine (NAC) to attenuate ischemia-reperfusion (I/R) injury in a canine model of autologous renal transplantation. METHODS Male mongrel dogs (15-20 kg) underwent left nephrectomy followed by flushing and static preservation of the kidney in University of Wisconsin (UW) solution for 48 hr. The treatment group… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 25 CITATIONS

Ischaemia-Reperfusion-Induced Kidney Injury

Docent Piet Finckenberg
  • 2014
VIEW 2 EXCERPTS
CITES BACKGROUND