Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats

@article{Yokel1976AttenuationOI,
  title={Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats},
  author={Robert A. Yokel and Roy Wise},
  journal={Psychopharmacology},
  year={1976},
  volume={48},
  pages={311-318}
}
Norepinephrine (NE) and dopamine (DA) receptor blockade differentially affected amphetamine self-administration. DA blockade (pimozide, 0.0625 to 0.5 mg/kg, or (+)-butaclamol, 0.0125 to 0.1 mg/kg) caused periods of increased rate of responding for amphetamine which were followed, in the case of higher doses, by response cessation. The response cessation produced by 0.5 mg/kg pimozide was not reversed by non-contingent amphetamine injections until well after the peak effect of the pimozide was… CONTINUE READING

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The effects of alphamethyl tyrosine on methamphetamine self - administration and brain catecholamine levels

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