Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B.

@article{Zhao1997AttenuationOI,
  title={Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B.},
  author={Allan Zijian Zhao and Hui Zhao and Jon Teague and Wakako Fujimoto and Joseph A. Beavo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 7},
  pages={3223-8}
}
Both insulin and insulin-like growth factor 1 (IGF-1) are known to reduce glucose-dependent insulin secretion from the beta cells of pancreatic islets. In this paper we show that the mechanism by which IGF-1 mediates this effect is in large part through activation of a specific cyclic nucleotide phosphodiesterase, phosphodiesterase 3B (PDE3B). More specifically, in both isolated pancreatic islets and insulin-secreting HIT-T15 cells, IGF-1 inhibits insulin secretion that has been increased by… CONTINUE READING

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