Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed patients by mirtazapine

Abstract

Rationale. It has been suggested that hypothalamic-pituitary-adrenocortical (HPA) system dysregulation plays an important role in the pathophysiology of depression and that normalization of HPA axis hyperactivity precedes successful treatment with antidepressants. Mirtazapine acts as an antagonist at presynaptic α2-receptors and at postsynaptic 5… (More)
DOI: 10.1007/s00213-002-1356-z

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@article{Schuele2003AttenuationOH, title={Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed patients by mirtazapine}, author={Cornelius Schuele and Thomas C. Baghai and Peter Zwanzger and Robin Ella and Daniela Eser and Frank Thomas Padberg and Hans-J{\"{u}rgen M{\"{o}ller and Rainer Rupprecht}, journal={Psychopharmacology}, year={2003}, volume={166}, pages={271-275} }