Attenuation of human influenza A viruses.

  title={Attenuation of human influenza A viruses.},
  author={A. S. Beare and M. L. Bynoe},
  journal={British medical journal},
  volume={4 5677},
The attenuation of two human influenza A viruses has been carried out, using the selection of inhibitor-resistant strains and multiple passages at low temperatures. A virus related to A2/Tokyo/3/67 was obtained in an inhibitor-resistant form. When this was compared with the inhibitor-sensitive strain in a volunteer trial it was relatively non-pathogenic. The second virus, A2/Hongkong/1/68, was subjected to much longer treatment, but nevertheless remained slightly sensitive to serum inhibitor… CONTINUE READING