Attenuation of fluctuating striatal synaptic dopamine levels in patients with Parkinson disease in response to subthalamic nucleus stimulation: a positron emission tomography study.

@article{Nimura2005AttenuationOF,
  title={Attenuation of fluctuating striatal synaptic dopamine levels in patients with Parkinson disease in response to subthalamic nucleus stimulation: a positron emission tomography study.},
  author={Taro Nimura and Keiichiro Yamaguchi and Tadashi Ando and Satoshi Shibuya and Takanori Oikawa and Atsuhiro Nakagawa and Reizo Shirane and Masatoshi Itoh and Teiji Tominaga},
  journal={Journal of neurosurgery},
  year={2005},
  volume={103 6},
  pages={968-73}
}
OBJECT The "wearing-off" phenomenon often hampers the treatment of Parkinson disease (PD). Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known to ameliorate the wearing-off phenomenon, the mechanism by which it does this remains unclear. As part of an inquiry into the mechanism of STN DBS, the authors measured synaptic dopamine levels in the striatum by performing positron emission tomography (PET) with [11C]raclopride. METHODS Three patients with PD who were… CONTINUE READING

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Effect of simple motor performance on regional dopamine release in the striatum in Parkinson disease patients and healthy subjects: a positron emission tomography study.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2002

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