• Corpus ID: 44002957

Attenuation of expression of cytokines, oxidative stress and inflammation by hepatoprotective phenolic acids from Thespesia populnea Soland ex Correa stem bark

  title={Attenuation of expression of cytokines, oxidative stress and inflammation by hepatoprotective phenolic acids from Thespesia populnea Soland ex Correa stem bark},
  author={P. Yuvaraj and Appian Subramoniam and Therasilin Louis and V. Madhavachandran and Mangamoori Lakshmi Narasu and Nagarjuna Herbal},
Recently a highly active hepatoprotective phenolic acids fraction (PF) has been isolated from Thespesia populnea stem bark. This fraction showed hepatoprotective action against toxic chemicals such as carbon tetrachloride, acetaminophen and thioacetamide. It also showed in vitro anti-Hepatis B viral activity in cultured cells. In the present study, follow up investigations were carried out to determine the effect of PF on the expression of TNF-alpha, IL-6 and IL-10 in acetaminophen challenged… 
2 Citations

Figures and Tables from this paper

Fatty acid, tocopherol, sterol compositions and antioxidant activity of three Garcinia seed oils

The fatty acid, tocopherol, and sterol contents of the extracted seed oils from three Garcinia species, including G. hanburyi Hook. f., G. multiflora Champ. ex Benth., and G. gaudichaudii Planch. &

Hepatoprotective property of Thespesia populnea against carbon tetrachloride induced liver damage in rats

The present study indicates that ethanol extract of T. populnea stem bark is promising for further studies leading to hepatoprotective drug development.

Hepatoprotective properties of phenolic acids from Thespesia populnea Soland ex. Correa

PF protected rats from acetaminophen and thioacetamide induced hepatotoxicity also and showed antihepatitis B viral activity in HepG2.2.15 cell line, which is promising for the development of a medicine for liver diseases.

Role of proinflammatory cytokines in acetaminophen hepatotoxicity.

Data suggest that TNF-alpha and IL-1 alpha are released in response to APAP intoxication and are responsible for certain pathological manifestations of APAP-induced hepatotoxicity.

Histopathology of Acetaminophen-Induced Liver Changes: Role of Interleukin 1α and Tumor Necrosis Factor α

It is suggested that TNF-α and IL-1α play an important role in the degree of damage and recovery that the liver undergoes following APAP intoxication.

Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease.

Analgesic and antiinflammatory effects of chalcones isolated from Myracrodruon urundeuva allemão.

The present work showed analgesic and antiinflammatory activities from a fraction containing three dimeric chalcones (chalcone enriched fraction - CEF), isolated from the stem-bark ethyl acetate

Pharmacological actions of Thespesia populnea relevant to Alzheimer's disease.

    M. VasudevanM. Parle
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2006