Attenuation of experimental proliferative vitreoretinopathy by inhibiting the platelet-derived growth factor receptor.

@article{Ikuno2000AttenuationOE,
  title={Attenuation of experimental proliferative vitreoretinopathy by inhibiting the platelet-derived growth factor receptor.},
  author={Yasushi Ikuno and Frederick T L Leong and Arūnas Kazlauskas},
  journal={Investigative ophthalmology & visual science},
  year={2000},
  volume={41 10},
  pages={
          3107-16
        }
}
PURPOSE The work from numerous laboratories has led to the idea that the growth factors such as platelet-derived growth factor (PDGF) contribute to proliferative vitreoretinopathy (PVR) in experimental models of the disease, as well as in humans. In support of this idea, the authors have previously reported that cells unable to respond to PDGF had a greatly reduced PVR potential, compared with PDGF-responsive versions of the same cells. The goal of this study was to test the effect of blocking… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Connective tissue growth factor as a mediator of intraocular fibrosis.

  • Investigative ophthalmology & visual science
  • 2008
VIEW 17 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED