Attenuation of experimental murine colitis by acanthoic acid from Acanthopanax koreanum.

Abstract

Acanthoic acid (AA) is a pimaradiene diterpene isolated from Acanthopanax koreanum. We examined the effect of AA in dextran sulfate sodium (DSS)-induced colitis. AA (100 mg/kg or 300 mg/kg) was administered p.o. daily for 7 days. AA significantly inhibited Disease Activity Index, histological score, and myeloperoxidase activity. Furthermore, AA markedly… (More)
DOI: 10.1007/s12272-010-2230-x

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