Attenuation of experimental hepatopulmonary syndrome in endothelin B receptor-deficient rats.

@article{Zhang2009AttenuationOE,
  title={Attenuation of experimental hepatopulmonary syndrome in endothelin B receptor-deficient rats.},
  author={Junlan Zhang and Yiqun Ling and Liping Tang and Bao Luo and David M Pollock and Michael Brooks Fallon},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={296 4},
  pages={G704-8}
}
Experimental hepatopulmonary syndrome (HPS) after common bile duct ligation (CBDL) in rat is accompanied by increased lung vascular endothelial endothelin B (ETB) receptor expression and increased circulating levels of endothelin-1 (ET-1). The onset of HPS is hypothesized to be triggered by ET-1/ETB receptor activation of endothelial nitric oxide synthase (eNOS)-derived NO production in the pulmonary endothelium. However, whether functional pulmonary vascular ETB receptors are required for the… CONTINUE READING
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