Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin.

@article{Chen2010AttenuationOE,
  title={Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin.},
  author={Xiaohong Chen and Rongbiao Pi and Yan Zou and Mei Liu and Xiaomeng Ma and Ying Jiang and Xuexuan Mao and Xueqiang Hu},
  journal={European journal of pharmacology},
  year={2010},
  volume={629 1-3},
  pages={40-6}
}
Osthole, a natural coumarin, is known to have a variety of pharmacological and biochemical uses and is considered to have potential therapeutic applications. Here we examined the effects of osthole on the central nervous system demyelination in experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis and its mechanism(s). C57 BL/6 mice immunized with myelin oligodendrocyte glycoprotein 35-55 amino acid peptide were treated with osthole at day 7 post immunization (7 p.i… CONTINUE READING
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