Attenuation of experimental atherosclerosis by interleukin-19.

  title={Attenuation of experimental atherosclerosis by interleukin-19.},
  author={Stephen C Ellison and Khatuna Gabunia and Sheri E. Kelemen and Ross N. England and Rosario G Scalia and James M. Richards and Anthony Orr and James G. Traylor and Thomas Rogers and William Cornwell and Lisa M Berglund and Isabel Gonçalves and Maria F. Gomez and Michael V. Autieri},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={33 10},
OBJECTIVE Interleukin-19 (IL-19) is a putative Th2, anti-inflammatory interleukin. Its expression and potential role in atherogenesis are unknown. IL-19 is not detected in normal artery and is expressed to a greater degree in plaque from symptomatic versus asymptomatic patients, suggesting a compensatory counter-regulatory function. We tested whether IL-19 could reduce atherosclerosis in susceptible mice and identified plausible mechanisms. APPROACH AND RESULTS LDLR(-/-) mice fed an… CONTINUE READING


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and vascular smooth muscle cell activation in AIF - 1 transgenic mice fed a high - fat diet

  • Rateri DL Daugherty A
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