Attenuation of ethanol intoxication by alpha-2 adrenoceptor antagonists.

  title={Attenuation of ethanol intoxication by alpha-2 adrenoceptor antagonists.},
  author={Richard G. Lister and Michael J. Durcan and David J. Nutt and Markku Linnoila},
  journal={Life sciences},
  volume={44 2},
The interaction of a highly potent and selective alpha-2 adrenoceptor antagonist, atipamezole with ethanol was investigated in tests assessing a number of ethanol's behavioral effects. Atipamezole antagonized ethanol's effects on directed exploration in a holeboard test, reduced observer-rated intoxication and also reduced the duration of loss of righting reflex caused by ethanol. Similar effects were produced by another alpha-2 adrenoceptor antagonist idazoxan. The magnitude of the effects was… CONTINUE READING

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