Attenuation of dengue virus infection by adeno-associated virus-mediated siRNA delivery

@article{Zhang2004AttenuationOD,
  title={Attenuation of dengue virus infection by adeno-associated virus-mediated siRNA delivery},
  author={Weidong Zhang and Rajeswari Singam and Gary R. Hellermann and Xiaoyuan Kong and H Ramirez San Juan and Richard Funk Lockey and Shwu Jiuan Wu and Kevin Randall Porter and Shyam Sundar Mohapatra},
  journal={Genetic Vaccines and Therapy},
  year={2004},
  volume={2},
  pages={8 - 8}
}
BACKGROUND: The need for safe and effective treatment of dengue virus (DEN), a class A agent that causes dengue hemorrhagic fever/dengue shock syndrome, has been a critical global priority. An effective vaccine for DEN is not yet available. In this study the possibility of attenuating DEN infection using adeno-associated virus (AAV)-encoded short interfering RNAs (siRNA) was examined in Vero cells and human dendritic cells (DCs). METHODS: A cassette encoding siRNA targeted to a 3' untranslated… CONTINUE READING
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