Attenuation of cyclosporine A-induced vascular toxicity by ramipril.


We wished to determine whether chronic inhibition of angiotensin-converting enzyme (ACE) prevents the vascular toxicity of cyclosporine A (Cx). In aortas isolated from rats treated with ramipril [10 mg/kg/day orally (p.o.) for 4 weeks], the endothelium-dependent relaxations to acetylcholine (ACh) were potentiated (the area under the curve (AUC) decreased… (More)


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@article{Berkenboom1994AttenuationOC, title={Attenuation of cyclosporine A-induced vascular toxicity by ramipril.}, author={Guy Berkenboom and Dmitri Br{\'e}kine and Philippe Unger and B{\'e}atrice Gulbis and Jeanine Fontaine}, journal={Journal of cardiovascular pharmacology}, year={1994}, volume={24 1}, pages={17-21} }