Attenuation of colistin bactericidal activity by high inoculum of Pseudomonas aeruginosa characterized by a new mechanism-based population pharmacodynamic model.

@article{Bulitta2010AttenuationOC,
  title={Attenuation of colistin bactericidal activity by high inoculum of Pseudomonas aeruginosa characterized by a new mechanism-based population pharmacodynamic model.},
  author={Jurgen B. Bulitta and Jenny C Yang and Liliana Yohonn and Neang S Ly and Silvia V. Brown and Rebecca E D'Hondt and William J. Jusko and Alan Forrest and Brian T. Tsuji},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 5},
  pages={2051-62}
}
Colistin is increasingly being utilized against Gram-negative pathogens, including Pseudomonas aeruginosa, resistant to all other antibiotics. Since limited data exist regarding killing by colistin at different initial inocula (CFUo), we evaluated killing of Pseudomonas aeruginosa by colistin at several CFUo and developed a mechanism-based mathematical model accommodating a range of CFUo. In vitro time-kill experiments were performed using >or=8 concentrations up to 64 x the MIC of colistin… CONTINUE READING

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