Attenuation of cold stress-induced exacerbation of cardiac and adipose tissue pathology and metabolic disorders in a rat model of metabolic syndrome by the glucocorticoid receptor antagonist RU486

@article{Nagasawa2016AttenuationOC,
  title={Attenuation of cold stress-induced exacerbation of cardiac and adipose tissue pathology and metabolic disorders in a rat model of metabolic syndrome by the glucocorticoid receptor antagonist RU486},
  author={K. Nagasawa and N. Matsuura and Y. Takeshita and S. Ito and Y. Sano and Y. Yamada and A. Uchinaka and T. Murohara and K. Nagata},
  journal={Nutrition \& Diabetes},
  year={2016},
  volume={6}
}
Objectives:Chronic stress affects the central nervous system as well as endocrine, metabolic and immune systems. However, the effects of cold stress on cardiovascular and metabolic disorders in metabolic syndrome (MetS) have remained unclear. We recently characterized DahlS.Z-Leprfa/Leprfa (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of MetS. We have now investigated the effects of chronic cold stress and glucocorticoid receptor (GR… Expand
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