Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms

@article{RuediBettschen2009AttenuationOC,
  title={Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms},
  author={Daniela Rüedi-Bettschen and James K. Rowlett and Roger D. Spealman and Donna M Platt},
  journal={Psychopharmacology},
  year={2009},
  volume={210},
  pages={169-177}
}
RationaleKappa agonists can attenuate reinstatement of cocaine-seeking behavior induced by cocaine priming. The mechanisms underlying this effect have not been characterized fully but may have a serotonergic component as kappa agonists also increase the release of serotonin (5-hydroxytryptamine, 5-HT).ObjectivesThis study investigated the role of kappa opioid receptor and 5-HT mechanisms in kappa agonist-induced attenuation of cocaine priming in monkeys.MethodsSquirrel monkeys were trained to… Expand
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