Attenuation of bleomycin-induced lung fibrosis by oxymatrine is associated with regulation of fibroblast proliferation and collagen production in primary culture.

@article{Chen2008AttenuationOB,
  title={Attenuation of bleomycin-induced lung fibrosis by oxymatrine is associated with regulation of fibroblast proliferation and collagen production in primary culture.},
  author={Xiaohong Chen and Renshan Sun and Jianming Hu and Ziyao Mo and Zifeng Yang and Dongjiang Liao and Nanshan Zhong},
  journal={Basic & clinical pharmacology & toxicology},
  year={2008},
  volume={103 3},
  pages={278-86}
}
There is no satisfactory treatment for pulmonary fibrosis, which is characterized by altered control of proliferation of mesenchymal fibroblasts and extracellular matrix production. Oxymatrine is an alkaloid extracted from the Chinese herb Sophora japonica (Sophora flavescens Ait.) with capacities of anti-inflammation, inhibition of immune reaction, antivirus, protection against acute lung injury and antihepatic fibrosis. In this study, the effect of oxymatrine on pulmonary fibrosis was… CONTINUE READING
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