Attenuation of berberine on lipopolysaccharide-induced inflammatory and apoptosis responses in β-cells via TLR4-independent JNK/NF-κB pathway.

@article{Wang2013AttenuationOB,
  title={Attenuation of berberine on lipopolysaccharide-induced inflammatory and apoptosis responses in β-cells via TLR4-independent JNK/NF-κB pathway.},
  author={Ying Wang},
  journal={Pharmaceutical biology},
  year={2013}
}
  • Ying Wang
  • Published 2013 in Pharmaceutical biology
Abstract Context: Toll-like receptor 4 (TLR4)-independent inflammatory and apoptosis responses contribute to β-cell failure in diabetes mellitus (DM). Berberine (BBR), a bioactive isoquinoline derivative alkaloid, ameliorates the inflammatory response in DM. Objective: This study explored the protective mechanisms of BBR on TLR4-independent inflammation response in β cells. Materials and methods: Lipopolysaccharide (LPS; 100 ng/ml) was used to induce the inflammatory response in NIT-1 and rat… CONTINUE READING
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