Attenuation of antigen-induced airway hyperresponsiveness and inflammation in CXCR3 knockout mice

@inproceedings{Lin2011AttenuationOA,
  title={Attenuation of antigen-induced airway hyperresponsiveness and inflammation in CXCR3 knockout mice},
  author={Yi Zhen Lin and Haibo Yan and Y I Xiao and Hongmei Piao and Ruolan Xiang and Lei Jiang and Huaxia Chen and Kewu Huang and Zijian Guo and Wei-xun Zhou and Bao Shi Lu and Jinming Gao},
  booktitle={Respiratory research},
  year={2011}
}
BACKGROUND CD8+ T cells participate in airway hyperresponsiveness (AHR) and allergic pulmonary inflammation that are characteristics of asthma. CXCL10 by binding to CXCR3 expressed preferentially on activated CD8+ T cells, attracts T cells homing to the lung. We studied the contribution and limitation of CXCR3 to AHR and airway inflammation induced by ovalbumin (OVA) using CXCR3 knockout (KO) mice. METHODS Mice were sensitized and challenged with OVA. Lung histopathological changes, AHR… CONTINUE READING

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