Attenuation of allergic contact dermatitis through the endocannabinoid system.

  title={Attenuation of allergic contact dermatitis through the endocannabinoid system.},
  author={Meliha Karsak and Evelyn Gaffal and Rahul A Date and Lihua Wang-Eckhardt and Jennifer Rehnelt and Stefania Petrosino and Katarzyna Starowicz and Regina Steuder and Eberhard Schlicker and Benjamin F Cravatt and Raphael Mechoulam and Reinhard Buettner and Sabine Werner and Vincenzo Di Marzo and Thomas T{\"u}ting and Andreas Zimmer},
  volume={316 5830},
Allergic contact dermatitis affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes for occupational diseases. In an animal model for cutaneous contact hypersensitivity, we show that mice lacking both known cannabinoid receptors display exacerbated allergic inflammation. In contrast, fatty acid amide hydrolase-deficient mice, which have increased levels of the endocannabinoid anandamide, displayed reduced allergic responses in the skin. Cannabinoid… CONTINUE READING
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