Attenuation of alcohol intake by Ibogaine in three strains of alcohol-preferring rats

  title={Attenuation of alcohol intake by Ibogaine in three strains of alcohol-preferring rats},
  author={Amir H. Rezvani and David H. Overstreet and Yue-Wei Leef},
  journal={Pharmacology Biochemistry and Behavior},

Thyrotropin releasing hormone analog TA-0910 suppresses alcohol intake in alcohol drinking African green monkeys.

It is suggested that activation of brain thyrotropin-releasing hormone systems reduces alcohol intake in primates and that tolerance to this effect is not evident within 5 days under a limited access schedule.

Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice

The results show that ethanol, but not ibogaine, induced CPP in mice, adding to the literature suggesting that psychedelics, in particular ibogane, may have therapeutic properties for the treatment of alcohol use disorder at doses that do not have rewarding effects per se.

Electroacupuncture Reduces Voluntary Alcohol Intake in Alcohol-preferring Rats via an Opiate-sensitive Mechanism

Electroacupuncture has been shown to modify the effects of various drugs of abuse, including alcohol, and activation of the endogenous opiate system may be responsible for EA’s effects on alcohol intake in the alcohol-dependent iP rats.

Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives.

NPI-028 and one of its pure components, NPI-031G, selectively reduced alcohol intake in alcohol-preferring rats and significantly reduced ethanol intake in FH rats without affecting food or water intake.

Alcohol consumption and gustatory hedonic profiles in Wistar-Kyoto hyper- and normoactive rat strains.

It is concluded that the difference in alcohol consumption is mainly due to the low intake of the WKY rats and it is suggested that their different level of consumption might result from the particular behavioural profile of these rats.

Behavioural features of alcohol-preferring rats: focus on inbred strains.

Immobility in the forced swim test and high voluntary consumption of alcohol, two prominent features of the FH/Wjd rat strain which may be related to its serotonergic dysfunction, appear to be mediated by different genetic factors.



Attenuation of alcohol preference in alcohol-preferring rats by a novel TRH analogue, TA-0910.

Findings indicate involvement of TRH systems in ethanol preference and suggest that centrally acting TRH analogues may be therapeutic in the treatment of alcoholism.

The subchronic effects of the TRH analog TA-0910 and bromocriptine on alcohol preference in alcohol-preferring rats: development of tolerance and cross-tolerance.

Findings indicate that tolerance to the effects of TA-0910 on alcohol intake occurs and suggest dopamine involvement in the mechanism of action of TA -0910 in reducing alcohol intake in P rats.

Stimulus effects of ibogaine in rats trained with yohimbine, DOM, or LSD