Attenuation of age-related muscle wasting and weakness in rats after formoterol treatment: therapeutic implications for sarcopenia.

@article{Ryall2007AttenuationOA,
  title={Attenuation of age-related muscle wasting and weakness in rats after formoterol treatment: therapeutic implications for sarcopenia.},
  author={James G. Ryall and Jonathan D Schertzer and Gordon S Lynch},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2007},
  volume={62 8},
  pages={813-23}
}
We investigated the potential of the beta(2)-adrenoceptor agonist formoterol to increase mass and force-producing capacity of extensor digitorum longus (EDL) and soleus muscles from young, adult, and old rats. In addition, we examined the result of formoterol withdrawal. Young (3 month), adult (16 month), and old (27 month) F344 rats were treated with either formoterol (25 microg/kg/day, i.p.) or saline vehicle for 4 weeks. Another group of rats (for each age) was similarly treated with… CONTINUE READING