Attenuation of adrenomedullin-induced renal vasodilatation by NG-nitro L-arginine but not glibenclamide.

@article{Miura1995AttenuationOA,
  title={Attenuation of adrenomedullin-induced renal vasodilatation by NG-nitro L-arginine but not glibenclamide.},
  author={Katsuyuki Miura and Tsuneyuki Ebara and Michiaki Okumura and Takeshi Matsuura and Sae Chul Kim and Tokihito Yukimura and Hiroshi Iwao},
  journal={British journal of pharmacology},
  year={1995},
  volume={115 6},
  pages={917-24}
}
1. The present study was conducted in order to elucidate the in vivo contribution of nitric oxide (NO) and the glibenclamide-sensitive potassium channel in the renal action of adrenomedullin in anaesthetized dogs. 2. Intrarenal arterial infusion of adrenomedullin (20 ng kg-1 min-1) elicited a pronounced increase in renal blood flow with no changes in systemic blood pressure. The renal vasodilator action of adrenomedullin was markedly attenuated by pretreatment with NG-nitro L-arginine (L-NOARG… CONTINUE READING

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